J21170 - V1.2 - B.FLT.5014 - Candidate compound testing in a methanogen model
A range of solutions are being developed to reduce methane emissions from cattle.
| Project start date: | 20 May 2022 |
| Project end date: | 01 November 2023 |
| Publication date: | 13 February 2024 |
| Project status: | Completed |
| Livestock species: | Grain-fed Cattle |
| Relevant regions: | National |
Summary
There are limited options available to reduce methane emissions from cattle, and a greater range of cost effective and efficacious solutions are required. A previous project (B.FLT.5007) developed a range of compounds to target a key pathway in methanogenesis and screened these compounds in an E. coli model. This project aimed to continue the development of these compounds by testing if inhibition occurs at commercially viable concentrations in a methanogen model.
Objectives
The objective of this project was to screen a range of methane inhibiting compounds at commercially viable concentrations in an in vitro methanogen model.
Key findings
This project successfully screened compounds for inhibition of methanogenesis in an in vitro methanogen model.
Key findings included:
-greater understanding of biochemical pathways for hydrogenotrophic methanogen species
-physiochemical properties for consideration when designing compounds for methane inhibition
-determining efficacy of methane inhibition in an in-vitro methanogen model versus known inhibitors to guide decisions on further product development and investment.
A range of candidate compounds were developed and are currently being patented by MLA for further commercialisation and research discussions.
Benefits to industry
The key findings and design of this study will inform future research using in vitro models, and furthers understanding of methanogenesis biochemistry pathways that can be targeted for inhibition of methane.
MLA action
As a part of the red meat industry's CN30 target, MLA will continue to invest in research to develop and validate commercially viable solutions that reduce methane emissions.
Future research
Future research will continue to increase understanding of rumen and methanogen biochemical pathways, rigorously validate methane reducing supplements, and develop solutions the are commercially viable for use in the supply chain.
